Endocrine Abstracts

Introduction: Perhaps due to a current global epidemic of “overdiagnosis”, papillary thyroid microcarcinoma (PTM) is now the commonest endocrine malignancy (BMJ 348: 3045, 2014). Current management options vary from lobectomy or total thyroidectomy to “active surveillance”. An alternative approach, used successfully for eliminating neck nodal metastases (JCEM 96: 2717, 2011), is ultrasound-guided percutaneous ethanol ablation (UPEA). Here we present our exp...

Background: To determine whether radioiodine remnant ablation (RRA) reduces cause-specific mortality (CSM) or tumor recurrence (TR) rates after bilateral thyroidectomy (BT) in low-risk adult papillary thyroid carcinoma (APTC) patients treated with curative intent, we compared outcome in 1836 stage I patients having BT alone with 832 having BT+RRA.Methods: THEN cohort (1966-1990) comprised 809 patients; 36% having RRA within 6 postoperative months. NOW co...

Objectives: Childhood papillary thyroid cancer (CPTC) often presents with advanced disease but rarely results in cause-specific mortality (CSM). Controversy remains regarding optimal management and association with non-thyroid second primary malignancies (NSPM). We analyzed outcome in 189 CPTC patients and assessed the influence of radioiodine remnant ablation (RRA) and the utility of the American Thyroid Association risk-groups (ATA-R) in predicting tumor recurrence (TR)....

Background: UPEA for LRR in PTC was introduced in 1993 (JCEM 96:2717, 2011). It is not appreciated that such non-invasive ablations can often be repeated over decades (Surgery 154:1448, 2013). Skin metastases (SM) from thyroid carcinoma are typically associated with disseminated disease; average survival after SM diagnosis is 19 months (JAAD 36:531, 1997). Our case provides insights into managing LRR and SM in LRPTC.Clinical case: In 2004, an open biopsy...

Introduction: Ethanol ablation (EA) of “persistent or recurrent” neck nodal metastases (NNM) in adult papillary thyroid carcinoma (APTC) patients was first introduced in 1993 to clinical endocrine oncologic practice (JCEM 2011;96: 2717). At Mayo Clinic we have been impressed by the efficacy of EA in controlling postoperative NNM in stage I APTC patients. We now describe the long-term outcome results of EA in controlling recurrent NNM in 41 patients consecutively mana...

Introduction: Childhood papillary thyroid carcinoma (CPTC), despite bilateral thyroidectomy (BT), nodal resection and radioiodine remnant ablation (RRA), recurs within neck nodal metastases (NNM) in >30% within 20 postoperative years. However, these NNM are usually treated with re-operation or further radioiodine; US-guided ethanol ablation (EA) may be considered (j.sempedsurg.2020.150920) for patients with limited numbers of NNMMethods: We studied l...

The study aims were to characterize patients with papillary thyroid microcarcinoma (PTM) and to provide data on long-term outcome. About 900 patients with PTM (tumor size 1 cm or less) had treatment at our centre during 1945–2004. Follow-up extended to 54 years. Mean follow-up for 638 survivors was 13.5 years. Recurrence and mortality details were derived from a computerized database. Median tumour size was 7 mm. About 99% of tumors were grade 1; 98% were not locally inva...